The hikaru genki (hig) gene was identified by analysis of Drosophila mutants exhibiting reduced locomotor behavior. This gene is expressed in a subset of neurons in the CNS of embryos and continues to be expressed in the nervous system until the adult stage. Hig is a secretory protein with an immunoglobulin (Ig) domain and a maximum of five complement control protein (CCP) domains (Hoshino et al., 1993). Immunoelectron microscopy reveals that Hig localizes to the synaptic clefts of subsets of synapses in the adult brain and in nascent synapses during pupal stages (Hoshino et al., 1996). This protein is present in the secretory apparatus (Hoshino et al., 1996) and is secreted from cultured cells to the medium (Hoshino et al., 1999). Mutant phenotypes of hig flies can be rescued by transient expression of Hig during middle pupal stages, suggesting that Hig plays a role in differentiation of synapses (Hoshino et al., 1996).
genki genki 006
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